产品详情介绍
粒细胞-巨噬细胞集落刺激因子（Granulocyte-Macrophage Colony-Stimulating Factor, GM-CSF）是一种重要的细胞因子，它在免疫反应和炎症过程中起着关键作用。GM-CSF主要促进粒细胞和巨噬细胞的增殖、分化和活化，同时调控T细胞的响应，对免疫系统的防御机制至关重要[1]。GM-CSF的表达受到精细的调控，这对于维持免疫平衡和防止自身免疫疾病的发展至关重要[2]。除了在免疫细胞中的重要作用，GM-CSF还可以通过激活p70 S6核糖体蛋白激酶信号通路来促进中性粒细胞的趋化 [3]。GM-CSF的这些特性使其成为治疗自身免疫疾病和炎症性疾病的潜在靶点[4-5]。
[1] Shi Y, Liu CH, Roberts AI, Das J, Xu G, Ren G, Zhang Y, Zhang L, Yuan ZR, Tan HS, Das G, Devadas S. Granulocyte-macrophage colony-stimulating factor (GM-CSF) and T-cell responses: what we do and don't know. Cell Res. 2006 Feb;16(2):126-33.
[2] Gasson JC, Fraser JK, Nimer SD. Human granulocyte-macrophage colony-stimulating factor (GM-CSF): regulation of expression. Prog Clin Biol Res. 1990;338:27-41.
[3] Gomez-Cambronero J, Horn J, Paul CC, Baumann MA. Granulocyte-macrophage colony-stimulating factor is a chemoattractant cytokine for human neutrophils: involvement of the ribosomal p70 S6 kinase signaling pathway. J Immunol. 2003 Dec 15;171(12):6846-55.
[4] Shiomi A, Usui T, Mimori T. GM-CSF as a therapeutic target in autoimmune diseases. Inflamm Regen. 2016 Jul 5;36:8. doi: 10.1186/s41232-016-0014-5.
[5] van Nieuwenhuijze A, Koenders M, Roeleveld D, Sleeman MA, van den Berg W, Wicks IP. GM-CSF as a therapeutic target in inflammatory diseases. Mol Immunol. 2013 Dec;56(4):675-82.
